The main location of The Rogosin Institute is on New York City's Upper East Side in The Helmsley Medical Tower next to the world-renowned New York-Presbyterian Hospital/Cornell.

The Institute has additional facilities:

in the New York-Presbyterian/Cornell:

The Rogosin Institute Wing, The Rogosin Institute Ralph J. Bunche Dialysis and Apheresis Center

in The Rockefeller University:

The Iris & B. Gerald Cantor Research Laboratories - Smith Hall second floor

Maurice R. Greenberg Comprehensive Lipid Control Center laboratories and offices - Smith Hall, fifth floor

on East 64th Street: Comprehensive Lipid Control Center; Dreyfus Health Foundation

East 71st Street: RI Immunogenetics & Transplantation Laboratory

East 72nd Street: RI David D. Thompson Transplantation Center

East 74th Street: RI finance and human resources offices

in Xenia, Ohio:

RI Research in Diabetes and Cancer