The Rogosin Institute

Autosome
A chromosome other than a sex chromosome

Azotemic
An excess of urea and other nitrogenous wastes in the blood as a result of kidney insufficiency

Aneurysm an abnormal blood
Filled dilatation of a blood vessel and especially an artery resulting from disease of the vessel wall

Antihypertensive
Used or effective against high blood pressure

Coagulation
A change from a liquid to a thickened state

Codon
A specific sequence of three consecutive nucleotides that is part of the genetic code and that specifies a particular amino acid in a protein or starts or stops protein synthesis

Encapsulate
To surround, encase, or protect in or as if in a capsule

Expanded donor
A donor that is not considered to be ’ideal’ or ’standard’. Characteristics may include advanced donor age, prior infection with hepatitis B or hepatitis C, hypertension or diabetes mellitus, The term ’expanded’ is used because an expansion of the donor pool is considered to increase transplantation.

Hematuria
The presence of blood or blood cells in the urine

Hypercholesterolemia
The presence of excess cholesterol in the blood

Intracranial
Situated or occurring within skull (cranium)

Inherited
To receive from a parent or ancestor by genetic transmission

Irreversibly
Incapable of being reversed

Missense mutation
A genetic mutation involving alteration of one or more codons so that different amino acids are determined and may be non functional

Nocturia
Urination at night especially when excessive

Polymorphism
The quality or state of existing in or assuming different forms

Pharmacogenomics
A biotechnological science that combines the techniques of medicine, pharmacology, and genomics and is concerned with developing drug therapies to compensate for genetic differences in patients which cause varied responses to a single therapeutic regimen

Receptor
A cell or group of cells that receives stimuli

Rejection
an immune response in which foreign tissue (as a transplanted organ) is attacked by immune system components (as antibodies, T cells) of the recipient organism

Serum
Blood

Truncation mutation
A genetic mutation that may shorten the amino acid sequence

Ultrasound
The diagnostic or therapeutic use of ultrasound and especially a noninvasive technique involving the formation of a two- dimensional image used for the examination and measurement of internal body structures and the detection of bodily abnormalities -- called also echography, sonography, ultrasonography

Ureter
One of a pair of thick-walled tubes that transports urine from the kidney to the bladder.

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